r/Tirzeglutide: rules, karma requirements and posting culture

Who posts here

Posters assume you know the drug names and their shorthand, and plenty of questions are about mixing and measuring vials. But the questions themselves are often basic, like whether to taper before switching, and they get answered patiently. The rules ban gatekeeping and shaming, so a newcomer question is safe here, it just may not get many replies.

• People on tirzepatide who have stalled and are weighing a switch to retatrutide, or back again.
• People stacking two GLP-1 drugs and asking how others time them.
• Long-term users in maintenance, some of them using a low dose for inflammation or menopause symptoms.
• First-timers describing their first injection and asking if what they feel is normal.
• A noticeable share of non-English speakers, with replies in Spanish, German, Italian and Portuguese.

Karma and account requirements

What it takes to get a post through in r/Tirzeglutide.

What you can post

What happens to a new post

Where the most recent posts ended up. Sample size: 400.

• Stayed up96%
• Removed by Reddit's filters4%
• Deleted by the author<1%

Reddit counts a removal by the subreddit's own AutoModerator rules as a moderator removal, so that share is not all human. Held by AutoModerator means the post is waiting in the mod queue.

The rules, in the mods' words

1. 1

   No Sources, Prices, or Sourcing Activity

   Posts or comments that mention sources, pricing, or include sourcing activity are not allowed and comments and posts will be removed. This includes all GLP-1s, peptides, medical supplies, references to geographical locations, requests for DMs, and invitations to other social media platforms. This is for the safety and preservation of the community.

2. 2

   Be Supportive & Respectful

   This community is a place for support. Avoid offensive language, personal attacks, gatekeeping, shaming, or any form of harassment toward your fellow Redditors.

3. 3

   No Sales, Self-Promotion, or Spam

   Refrain from sales, self-promotion, or spamming. Contribute meaningfully to discussions.

These are the rules as archived in January 2025. Rules change. Check the sidebar before you post.

The culture

r/Tirzeglutide is a small support group for people taking GLP-1 drugs, mostly tirzepatide and retatrutide, with semaglutide in the background. It is quiet: about two posts a day, and a typical post gets two comments. The point is shared experience, and the sidebar warns before anything else that sources are not allowed.

Almost half the posts are links, but nearly all of those are crossposts of a question someone already asked in a bigger GLP-1 subreddit. The original posts are short, about 44 words, and usually a single question: should I switch, should I stack, how do I go from a high dose of one drug to a low dose of another, is this reaction normal. The best-received post in recent months was a long personal account from someone in maintenance, linking a change in their appetite to new research on statins.

The live question is tirzepatide against retatrutide. Threads asking which is better draw the most comments, and the replies are personal histories rather than verdicts: one drug gave someone diarrhea, the other made someone tired, and several regulars say it differs from person to person.

What lands

• A direct comparison question between two drugs, which gets long first-hand replies.
• A long personal account with age, weight lost and time on the drug, especially from someone maintaining a loss.
• Questions about stacking or switching with your current dose and how long you have been on it stated up front.
• A clear description of a side effect, asking whether others have had it.

What gets removed or ignored

• Anything naming a source or a price, in a post or a comment.
• Mentioning your location, asking people to DM you, or inviting them to another platform. The rules treat all of these as sourcing.
• Sales and self-promotion, which have their own rule.
• Reddit's filters remove about 3.5% of posts. No moderator removals showed up in our sample, so a post that follows the rules is very likely to stay.

The unwritten rules

• Crossposting your question from a larger GLP-1 subreddit is normal here and nobody minds.
• Comments run longer than in most subreddits, about 22 words, because people explain their own history before they answer.
• Replies are framed as what worked for the person writing. Expect several different answers and no consensus.
• If you slip on sourcing, expect other members to remind you it is off limits before a moderator gets to it.

Self-promotion

The rule is short: no sales, self-promotion or spam, and contribute to the discussion. Combined with the sourcing ban, which covers prices, DMs and links to other platforms, there is no route for a seller of any kind. A founder or brand would find a small, kind audience that is here to compare notes, not to hear about products.

How people write here

Typical post length

44 words

Typical title length

4 words

Titles phrased as a question

27%

Typical comment length

22 words

Comments that include a link

3%

Posts that carry a flair

19%

The regulars

The accounts that showed up most in our sample. Worth reading before you post: they set the tone, and they are usually the first to reply.

Top keywords

The words and phrases that show up far more often here than in other communities, from recent posts in r/Tirzeglutide.

• tirz 122 posts
• tirzepatide 83 posts
• reta 72 posts
• dose 80 posts
• bac 41 posts
• bac water 37 posts
• vial 47 posts
• mg vial 18 posts
• syringe 20 posts
• switching 30 posts
• mg tirz 13 posts
• units 22 posts
• doses 22 posts
• triz 13 posts
• dosing 20 posts
• tirze 11 posts
• effects 31 posts
• side effects 27 posts
• appetite 20 posts
• mg ml 11 posts
• reconstituting 9 posts
• dosage 16 posts
• reconstituted 10 posts
• insulin syringe 7 posts
• suppression 13 posts
• mg dose 12 posts
• peptide 15 posts
• insulin 10 posts
• tirzepitide 7 posts
• appetite suppression 11 posts
• vials 13 posts
• sterile vial 4 posts
• pwede 4 posts
• tirzeptide 6 posts
• injection 16 posts
• bacteriostatic water 7 posts
• weight 30 posts
• tirz mg 5 posts
• food noise 14 posts
• splitting 8 posts

Posts that did well

• Statins & GLP-1 emerging research40 upvotes · 19 comments · Experience
• Reta or Tirz15 upvotes · 57 comments
• Debating between stacking with sema or go above fda approved dosing of tirz15 upvotes · 44 comments · Tirz/Sema Stack

Common questions