r/TirzepatideRX: rules, karma requirements and posting culture
About 46,000 people on tirzepatide, many of them on compounded vials. Friendly and practical, light on rules, and wary of new accounts that look like shills.
TirzepatideRX · Open on Reddit · Test your post for this subreddit
- Members
- 46k
- Created
- 2024
- New posts a day
- 28.7
- Comments on a typical post
- 8
- New posts removed
- 4%
The short answer
r/TirzepatideRX publishes no karma or account age requirement, and there are only four rules. About 95% of posts stay up, no flair is needed, and the room is mostly progress photos and practical questions about doses, side effects and maintenance. Talk about where to get tirzepatide is allowed only for doctor-prescribed sources, and overseas or research peptide talk is banned. Spam earns a ban without warning, so post as a patient with real experience, not a pitch.
Who posts here
People in their first weeks ask what to expect and get kind answers. Many members use compounded vials, so syringe units, vial life and dose splitting come up without explanation. Basic questions are welcome, but a post that asks the room to make a medical decision for you, like tapering off without your doctor, can come down.
- Patients on compounded tirzepatide comparing doses, vials and how their provider handles things.
- People on the brand-name pens, often after insurance stopped paying.
- Long-term users in maintenance, working out how to stretch or lower a dose.
- People weighing tirzepatide against semaglutide or retatrutide.
Karma and account requirements
What it takes to get a post through in r/TirzepatideRX.
| Karma | Not stated publicly. No karma rule or AutoModerator message was found. |
|---|---|
| Account age | Not stated publicly. Members do notice brand new accounts and may call them bots. |
| Post flair | Not used. Posts in our sample carry no flair. |
| Sourcing | Only doctor-prescribed sources may be discussed. Overseas and research peptide talk is banned, and members are asked to report it.Mods' wording: “No overseas, "research" peptide discussions.” |
| DMs | Do not invite people to message you.Mods' wording: “No soliciting DMs in the comments.” |
| Spam | Mods check the poster's profile when something is reported, and a spam history means a ban.Mods' wording: “If you have a history of spamming we will ban without warning.” |
What you can post
| Post type | Subreddit setting | Share of recent posts |
|---|---|---|
| Text | Allowed | 69% |
| Link | Allowed | 22% |
| Image | Allowed | 9% |
| Video | Allowed | 0% |
| Poll | Allowed | 0% |
What happens to a new post
Where the most recent posts ended up. Sample size: 400.
- Stayed up95%
- Removed by Reddit's filters1%
- Removed by moderators3%
- Deleted by the author<1%
Reddit counts a removal by the subreddit's own AutoModerator rules as a moderator removal, so that share is not all human. Held by AutoModerator means the post is waiting in the mod queue.
The rules, in the mods' words
- 1
No Spam
Any reported comments will be reviewed in addition to the user profile. If you have a history of spamming we will ban without warning.
- 2
No Sourcing Info, Unless from Doctor-Prescribed Sources
No overseas, "research" peptide discussions. This is how most subreddits get banned on this topic. Please report anyone promoting these options.
- 3
No Soliciting DMs
No soliciting DMs in the comments. Please report any DMs or DM requests.
- 4
Play Nice
We are cultivating a friendly and fun atmosphere where people can feel comfortable asking and sharing very personal experiences. Be nice to other subreddit members. Report any internet bullies.
These are the rules as archived in January 2025. Rules change. Check the sidebar before you post.
The culture
r/TirzepatideRX is a smaller, friendlier room than the big brand-name subreddits. About 46,000 members, close to 30 posts a day, and a typical post gets around eight comments. The rules ask members to keep things nice so people feel safe sharing very personal experiences, and most threads read that way.
Text is about two thirds of posts and links about a fifth. The top posts are progress photos with a number attached, like 100 pounds in 30 weeks or a first day under 200. Day to day it is practical questions: is this side effect normal, did I draw the right number of units, how do I find a maintenance dose, should I split my shot.
Because many members pay out of pocket for compounded tirzepatide, provider talk is everywhere: prices, shipping, customer service and refunds. The rule allows sourcing info only from doctor-prescribed sources, and the line it draws is research peptides. Retatrutide sits on that line. Some posts comparing it with tirzepatide stay up, and some are removed.
What lands
- Progress photos with starting weight, current weight and how long you have been on it.
- Honest posts about the downside, like loose skin or not feeling as happy as expected at goal.
- Practical reminders from experience, like a post telling people they still need to eat properly.
- Posts pushing back on the idea that using the medication is cheating.
What gets removed or ignored
- Research peptide and overseas sourcing talk, which the rules say gets subreddits banned.
- Complaints about a single provider, refunds or order problems. Several removed posts were like this. Our data does not show the reasons.
- Posts asking whether to change or stop a dose without a doctor.
- Duplicates. One story was posted three times and removed each time.
- Spam, and comments soliciting DMs.
The unwritten rules
- Expect skepticism if your account is new. Members are used to shills and say so.
- Give your numbers. Dose, weeks on it, starting and current weight get better answers than a bare question.
- Comments are short and plain, around 20 words, and only about 2% carry a link.
- Members swap provider names all day, but a post that reads like a review written for a company gets picked apart.
- Keep it kind. The rules ask members to report bullies, and the room is gentle with people who are struggling.
Self-promotion
The only rule is no spam, backed by a ban without warning for anyone whose profile shows a spam history. There is no carve-out for founders or providers. In practice the room is full of provider talk from patients, and members are quick to call out anything that looks like a company posting as a customer. If you are building something for people on this medication, say who you are, ask a real question, and leave the link out.
How people write here
- Typical post length
- 83 words
- Typical title length
- 5 words
- Titles phrased as a question
- 30%
- Typical comment length
- 20 words
- Comments that include a link
- 2%
When people post
- 0:00 UTC, 24
- 1:00 UTC, 27
- 2:00 UTC, 30
- 3:00 UTC, 18
- 4:00 UTC, 11
- 5:00 UTC, 9
- 6:00 UTC, 8
- 7:00 UTC, 6
- 8:00 UTC, 9
- 9:00 UTC, 4
- 10:00 UTC, 7
- 11:00 UTC, 9
- 12:00 UTC, 18
- 13:00 UTC, 14
- 14:00 UTC, 15
- 15:00 UTC, 28
- 16:00 UTC, 30
- 17:00 UTC, 17
- 18:00 UTC, 18
- 19:00 UTC, 19
- 20:00 UTC, 25
- 21:00 UTC, 19
- 22:00 UTC, 23
- 23:00 UTC, 12
New posts by hour of day, UTC.
The regulars
The accounts that showed up most in our sample. Worth reading before you post: they set the tone, and they are usually the first to reply.
Most active posters
- u/South_Opportunity_529 posts
- u/WangtaWang6 posts
- u/Standard_Try79845 posts
- u/sisteR9673 posts
- u/_KORPz3 posts
Most active commenters
- u/peony_chalk11 comments
- u/Wonderful-Tie-43908 comments
- u/Salt-Preference-24255 comments
- u/Grasshopper_pie5 comments
- u/Bells1314 comments
Top keywords
The words and phrases that show up far more often here than in other communities, from recent posts in r/TirzepatideRX.
- tirzepatide 111 posts
- tirz 79 posts
- dose 90 posts
- weight 90 posts
- lbs 71 posts
- lost 66 posts
- food noise 36 posts
- shot 38 posts
- effects 45 posts
- food 52 posts
- compounded 30 posts
- journey 35 posts
- pounds 32 posts
- eat 43 posts
- side effects 36 posts
- taking 53 posts
- appetite 30 posts
- loss 39 posts
- doctor 33 posts
- pharmacy 25 posts
- compounded tirzepatide 15 posts
- weight loss 26 posts
- medication 28 posts
- eating 33 posts
- body 34 posts
- side 50 posts
- compound 18 posts
- normal 38 posts
- starting 44 posts
- mg dose 15 posts
- lose 28 posts
- nausea 19 posts
- b12 14 posts
- doses 18 posts
- losing 25 posts
- feeling 33 posts
- gained 16 posts
- protein 21 posts
- felt 29 posts
- tirzepatide journey 6 posts
Posts that did well
- 30 weeks on Tirz🎉674 upvotes · 69 comments
- My journey from 4/30/26 to today.666 upvotes · 278 comments
- Birthday gift - an upgraded version of me609 upvotes · 71 comments
- 2 month results, so happy416 upvotes · 136 comments
- Things are going well…..398 upvotes · 30 comments
- For the first time in over 10 years, I am below 200lbs389 upvotes · 19 comments
- Don’t be afraid to stop using it!331 upvotes · 98 comments
- 265.5 -> 215.4 Officially 50 lbs down!302 upvotes · 32 comments
Common questions
How much karma do you need to post in r/TirzepatideRX?
No karma or account age requirement is published, and about 95% of posts stay up. Brand new accounts do get called bots by members, so a little comment history helps.
Can I promote my product in r/TirzepatideRX?
No. The rules ban spam, and mods review the profile of anyone reported, banning without warning if there is a spam history. Soliciting DMs is also banned. Share experience and ask questions instead.
Can you talk about compounded tirzepatide in r/TirzepatideRX?
Yes. Most of the room uses it. Sourcing talk is allowed only for doctor-prescribed sources, and overseas or research peptide discussion is banned.
Why was my r/TirzepatideRX post removed?
Few are. Moderators took about 3% of posts in our sample and Reddit's filters about 1%. The removed posts were mostly provider complaints, research peptide questions, dose changes without a doctor and duplicates.
Data as of October 15, 2026. Numbers come from public Reddit data (the Arctic Shift archive and GummySearch) sampled on this date. Removal share counts posts taken down by moderators, AutoModerator or Reddit's own filters. Banner and icon belong to the community. Moderators change rules without notice, so treat the sidebar as the final word.
